Analysis Note

ControlRat Brain Cerebellum lysate

Application

Western Blot Analysis:
Cat. # AB2212 recognizes pGluR4 (S862) at 1:5,000 in rat brain cerebellum Lysate.

Research CategoryNeuroscience

Anti-phospho GluR4 (S862) Antibody is an antibody against phospho GluR4 (S862) for use in WB.

Research Sub CategoryNeurotransmitters & Receptors

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. Direct phosphorylation of GluR4-containing receptors may regulate rapid excitatory synaptic transmission. In addition, phosphorylation of GluR4 S862. is both necessary and sufficient to deliver the receptor to the synapse and induce plasticity in early postnatal development.

Immunogen

Synthetic peptide from rat.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Serum with 0.05% NaN3

Quality

Routinely tested on rat brain cerebellum lysate.

Specificity

May react with mouse, human, primate and dog based on sequence homology. Reactivity with other species has not been tested.

Cat. # AB2212 recognzies phospho GluR4 (S862).

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Target description

~105 kDa